They are made of 100% digestible pork skin in U.S.D.A. inspected meat plants. They are top quality and USDA safety, then carefully slow roasted in their own natural juices up to 48 hours to achieve maximum, mouth-watering flavor dogs love. This product is made in the USA. It satisfies your dog's need to chew, cleans teeth, massages gums and prevents tartar buildup. They are low in fat and preservative free too!